Document Type

Article

Publication Date

3-2015

Abstract

Current methods of olfactory sensitivity testing are logistically challenging and therefore infeasible for use in in-home surveys and other field settings. We developed a fast, easy and reliable method of assessing olfactory thresholds, and used it in the first study of olfactory sensitivity in a nationally representative sample of U.S. home-dwelling older adults. We validated our method via computer simulation together with a model estimated from 590 normosmics. Simulated subjects were assigned n-butanol thresholds drawn from the estimated normosmic distribution and based on these and the model, we simulated administration of both the staircase and constant stimuli methods. Our results replicate both the correlation between the two methods and their reliability as previously reported by studies using human subjects. Further simulations evaluated the reliability of different constant stimuli protocols, varying both the range of dilutions and number of stimuli (6–16). Six appropriately chosen dilutions were sufficient for good reliability (0.67) in normosmic subjects. Finally, we applied our method to design a 5-minute, in-home assessment of older adults (National Social Life, Health and Aging Project, or NSHAP), which had comparable reliability (0.56), despite many subjects having estimated thresholds above the strongest dilution. Thus, testing with a fast, 6-item constant stimuli protocol is informative, and permits olfactory testing in previously inaccessible research settings.

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Original citation:

Kern, D. W., Schumm, L. P., Wroblewski, K. E., Pinto, J. M., Hummel, T., & McClintock, M. K. (2015). Olfactory thresholds of the US population of home-dwelling older adults: development and validation of a short, reliable measure. PloS One, 10(3). doi: 10.1371/journal.pone.0118589

Version

The article available for download here is the publisher version. Locate the version of record using the DOI below

DOI

http://dx.doi.org/10.1371/journal.pone.0118589

Creative Commons License

Creative Commons Attribution 4.0 License
This work is licensed under a Creative Commons Attribution 4.0 License.

Publication Title

PLOS One

Volume Number

10

Issue Number

3

First Page

1

Last Page

17

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