Analysis of Hemagglutinin-Mediated Entry Tropism of H5N1 Avian Influenza
Document Type
Article
Publication Date
2009
Abstract
Avian influenza virus H5N1 is a major concern as a potential global pandemic. It is thought that multiple key events must take place before efficient human-to-human transmission of the virus occurs. The first step in overcoming host restriction is viral entry which is mediated by HA, responsible for both viral attachment and viral/host membrane fusion. HA binds to glycans-containing receptors with terminal sialic acid (SA). It has been shown that avian influenza viruses preferentially bind to α2,3-linked SAs, while human influenza A viruses exhibit a preference for α2,6-linked SAs. Thus it is believed the precise linkage of SAs on the target cells dictate host tropism of the viruses.
Version
The work available here is the publisher version.
DOI
https://doi.org/10.1186/1743-422X-6-39
Publication Title
Virology Journal
Volume Number
6
Recommended Citation
Guo, Ying; Rumschlag-Booms, Emily; Wang, Jizhen; Xiao, Haixia; Yu, Jia; Wang, Jianwei; Guo, Li; Gao, George F.; Cao, Youjia; Caffrey, Michael; and Rong, Lijun, "Analysis of Hemagglutinin-Mediated Entry Tropism of H5N1 Avian Influenza" (2009). Biology Faculty Publications. 9.
https://neiudc.neiu.edu/bio-pub/9